Projects

Hospitals/clinics, including both NHS and private providers, delivering endovenous varicose vein procedures under local anaesthesia. Recruitment centres will need to have a pre-existing practice prior to the trial to prevent any learning curve effects.

Adults (>18 years)

Scheduled to undergo to undergo endovenous intervention of truncal varicose veins under local anaesthesia

Treatment technologies including radiofrequency, laser, mechanochemical, foam sclerotherapy and cyanoacrylate glue

Clinical indication for anticoagulation

Clinical contraindication to anticoagulation

Previous personal or family history of VTE

Thrombophilia

Inability to provide informed consent or consent by personal/professional legal representative

Female patients of childbearing age who have a positive pregnancy test

A positive test for SARS-CoV2 <3 months of procedure

Participants will have a duplex ultrasound scan performed locally at 21 – 28 days post-procedure. Remote follow ups will be conducted centrally by telephone, online or SMS at 7- and 90-days post-procedure by the coordinating centre (Imperial College London).

Primary outcome

Imaging confirmed lower limb DVT with or without symptoms, or PE with symptoms within 90 days of varicose vein treatment.

Secondary outcomes

Individual components of the composite outcome

Quality of life as determined by the validated outcome

Mortality

Incremental cost-effectiveness ratio (ICER) – cost-effectiveness

Sub-group analyses of the following risk assessment tools: DHRA tool, Caprini score

National Institute for Health Research (NIHR) – Health Technology Assessment (HTA).

Professor Alun Davies, Mr Daniel Carradice, Professor John Norrie, Mr Matthew Machin, Ms Laura Burgess, Professor Beverley Hunt, Ms Layla Bolton Saghdaoui, Mr Joseph Shalhoub, Dr Tamara Everington, Mr Manjit Gohel, Professor Mark Whiteley, Dr Steven Rogers, Miss Sarah Onida, Dr Benedict Turner, Mr Sandip Nandhra, Ms Rebecca Lawton, Mrs Annya Stephens-Boal, Mrs Carolyn Singer, Ms Joanne Dunbar